Protein Molecular Weight Markers
ABclonal Technology MS4A7 Rabbit pAb
This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
ABclonal Technology DHX8 Rabbit pAb
This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants.
ABclonal Technology ETV6 Rabbit pAb
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
ABclonal Technology S100A5 Rabbit pAb
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain.
ABclonal Technology KIRREL Rabbit pAb
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2, MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).
ABclonal Technology TLK1 Rabbit pAb
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology FXYD7 Rabbit pAb
This gene encodes a member of the FXYD-domain family of small membrane proteins, characterized by a 35-amino acid signature sequence starting with PFXYD, containing 7 invariant and 6 highly conserved amino acids. The FXYD family regulates ion transport and includes proteins like FXYD1 (phospholemman), FXYD2 (gamma subunit of Na,K-ATPase), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC), which induce channel activity in expression systems. Transmembrane topology for FXYD1 and FXYD2 shows the N-terminus extracellular and C-terminus cytoplasmic. FXYD7, a novel gene product, has not been characterized as a protein. The sequence is validated by similar human genomic data.
ABclonal Technology IPO11 Rabbit pAb
Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1, 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).
ABclonal Technology PPA1 Rabbit pAb
The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme.
ABclonal Technology TRNAU1AP Rabbit pAb
Enables RNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm. Predicted to be active in nucleus.
ABclonal Technology RASSF4 Rabbit pAb
The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants, however, most of the variants have not been fully described.
Perkin Elmer US LLC Organics High Sensitivity Plastic Nebulizer Complete Assembly with Pt/Ir Needle for PinAAcle
A complete High-Sensitivity plastic body nebulizer featuring Kalrez o-rings and Tantalum needle. The body is fabricated of inert plastic materials for maximum performance and corrosion resistance. This high-sensitivity nebulizer with Pt/Ir needle is for most solutions, but not for precious metal samples containing aqua regia. This assembly includes: Impact Bead, Qty. 1 (B0505086) Spacer, Qty. 1 (B3150531) Solvent Resistant O-Rings for Nebulizer Body, Qty. 2 (09200276) Plastic Nebulizer Body, Qty. 1 Spring, Qty. 2 (09920483) Locking Ring, Qty. 1 (N3151205) Solvent Resistant O-Ring for Capillary Needle Assembly, Qty. 1 (09200272) Solvent Resistant Pt/Ir Capillary Needle Assembly, Qty. 1 (N3160154) Fine Adjustment Nut, Qty. 1 (B3150462) Sample Tubing, Qty. 1 (B3150458) This nebulizer is compatible with the PerkinElmer PinAAcle 500/900F/900H/900T/900Z AA instruments.
ABclonal Technology PDHA2 Rabbit pAb
Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to act upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Is expressed in nervous system and testis. Orthologous to human PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2).
ABclonal Technology MRPL54 Rabbit pAb
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
ABclonal Technology ZSCAN21 Rabbit pAb
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.